Motilin Receptor

MLNR

Motilin Receptor

Related Products

Motilin receptor is a G protein-coupled receptor that binds motilin. Motilin in turn is an intestinal peptide that stimulates contraction of gutsmooth muscle. The main function of motilin is to increase the migrating myoelectric complex component of gastrointestinal motility and stimulate the production of pepsin. Motilin is called "housekeeper of the gut" because it improves peristalsis in the small intestine and clears out the gut to prepare for the next meal. A high level of motilin secreted between meals into the blood stimulates the contraction of the fundus and antrum and accelerates gastric emptying. It then contracts the gallbladder and increases the squeeze pressure of the lower esophageal sphincter. Other functions of motilin include increasing the release of pancreatic polypeptide and somatostatin.

Motilin Receptor Related Products (11):

By Effects:	Agonists (6) Antagonists (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-107642

MA-2029	Antagonist	99.79%
MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC₅₀=4.9 nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility.

HY-P1037

Motilin (26-47), human, porcine	Agonist
Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with K_i and EC₅₀ of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

HY-144401

DS-3801b	Agonist	99.18%
DS-3801b is a potent and non-macrolide agonist of GPR38. DS-3801b is expected to be novel gastrointestinal prokinetic agents for the research of functional gastrointestinal disorders such as gastroparesis and chronic constipation.

HY-P1541

Motilin, canine		98.74%
Motilin, canine is a 22-amino acid peptide. Motilin is a potent agonist for gastrointestinal smooth muscle contraction.

HY-106323

[Leu13]-Motilin	Agonist
[Leu13]-Motilin (KW-5139) is a motilin analogue. [Leu13]-Motilin stimulates gastrointestinal motility in the rabbit. [Leu13]-Motilin causes concentration-dependent contractions of the gastric antrum, duodenum, jejunum, ileum and the descending colon in vitro.

HY-P1233

ANQ-11125	Antagonist
ANQ-11125 is a potent and selective antagonist of motilin, with the pK_d of 8.24. ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit.

HY-P3176

Motilin, human, porcine
Motilin, human, porcine is a gastrointestinal hormone, which is released during fasting and after eating, or by drinking water. Motilin, human, porcine promotes enteric cholinergic activity in human stomach with an EC₅₀ of 33 nM, and thus modulates gastrointestinal motility function.

HY-P1233A

ANQ-11125 TFA	Antagonist
ANQ-11125 TFA is a potent and selective antagonist of motilin, with the pK_d of 8.24. ANQ-11125 TFA blocks motilide-induced contractions in vitro in the rabbit.

HY-105263

EM574	Agonist
EM574 is a potent motilin receptor agonist in the human gastric antrum and rabbit gastrointestinal tract in vitro. EM574 is an erythromycin derivative.

HY-P3680

[Nle13]-Motilin	Agonist
[Nle13]-Motilin, a motilin analogue, is a motilin receptor agonist.

HY-106258

Atilmotin	Agonist
OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pK_d of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents.

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